About Regenerative Medicine at Pain Doctor

Regenerative Medicine is; at its core, a conservative therapy. We do not utilize drugs, surgery or foreign materials to treat your painful condition. We use your very own cells to naturally repair and regenerate the affected tissues to reverse the damage. Powerful cells in your bone marrow called Mesenchymal Stem Cells can change and grow into new muscle, tendon, ligament, bone and even cartilage when called upon by the body. Growth factors provided by the platelets in your blood further stimulate and enhance this process. Marrow is harvested from the bone at the back of your waist through a relatively gentle, low volume aspiration.

From a simple blood draw, we can concentrate the platelets in a centrifuge. The combined injectate is skillfully targeted to the area needing treatment using state-of-the-art imaging techniques. In a time when we are flooded with more drugs and supplements than ever offering to treat injury and pain, people are demanding organic remedies and more natural cures. We are extremely proud to add this fantastic therapy to the already comprehensive list of services provided at Pain Doctor.

Regenerative medicine for pain explained by Denver, Golden, Aurora, Boulder, Broomfield, Jefferson, and Littleton Colorado’s top pain doctors

Regenerative medicine (RM) is a fast-growing, highly-developed technology that is increasingly being used to manage conditions such as chronic and acute pain. The FDA has not yet approved the use of regenerative treatments and medicine to remedy every pain condition and case. However, regenerative treatments and medicine might be appropriate for you, depending on your specific case.

Platelet Rich Plasma Draw BloodRegenerative medicine engineers biological, organic replacements for many body tissues. Regenerative treatments and medicine draws from advancements in several fields of technology and science such as biology, genetics, chemistry, medicine, engineering computer science, and robotics to engineer biological, organic replacements for bodily tissues. The substitutes, in turn, act to repair, improve, and maintain injured or diminished tissue function.

Regenerative medicine’s primary goal is to replace damaged, diseased, degenerating, or aging tissue with new tissue. Regenerative treatments and medicine replaces old tissue with engineered or regenerated human cells, tissues or organs. Regenerative medicine, or tissue engineering, uses a person’s present, live cells from tissue, biocompatible materials, and biochemical and physical elements to create constructs for repairing tissue.

Discoveries about the body’s own ability to order and heal itself and generate new tissue are the basis of regenerative medicine. Using technological advancements of regenerative medicine, scientists have developed new non-operative procedures that are not invasive for treating many common orthopedic conditions, such as arthritis, and injured bones, cartilages, ligaments, tendons, muscles, spinal discs, and other bodily tissues.

Technology And Science Behind Regenerative Medicine

Platelet Rich Plasma CenterfuigeWhat are stem cells? They are cells that are undifferentiated, which means that they can develop into different types of specialized body cells. Essentially, there are two kinds of stem cells: embryonic and adult stem cells. The first kind of stem cells—embryonic—are comprised of the embryo. They are the least developed type of stem cells. A fertilized egg starts to split and produce stem cells. These undeveloped cells inevitably distinguish themselves into all of the kinds of human body cells. Present in animals of all ages, the stem cells that are called adult stem cells are within already developed tissue, including your skin, muscles, brain, bones, and blood. Adult stem cells within your presently-developed matter divide often and continually remake new, specialized cells to replace lifeless or missing cells. In this way, they help repair your body tissue.

Scientists have conducted stem cell research for a great deal of years; they have studied the regenerative properties of stem cells, particularly that they can transform into every kind of body tissue. It is believed that, because of their regenerative properties, stem cells have potential for countless clinical functions in the medical field and in health care. This includes developing and progressing the therapy for heart disease, diabetes (Type I), stroke, hearing loss, vision loss, rheumatoid arthritis, osteoarthritis, injuries of the spinal cord, severe burns, Parkinson’s disease, Alzheimer’s disease, and Duchene’s muscular dystrophy. Many medical researchers and scientists anticipate that stem cell advancements ultimately will allow for the repair and replacement of the unhealthy or impaired tissues at the crux of these conditions.

Regenerative medicine had so much potential that it appeared on the market for sale and purchase almost immediately. The prospect of creating all types of human body tissue inspired enthusiasm in the medical and scientific community. Nevertheless, several problems impede the progress of leveraging regenerative treatments and medicine for many potential applications. For example, it is a problem that, unlike other types of tissue—tissue of both skin and tendon or cartilage—do not need a lot of development of capillaries (or vascularization). Therefore, more basic methods—such as combining cells together—are required for the generating process to engineer skin and cartilage tissue.

Ethical Considerations Of Regenerative Medicine

The political and ethical debates around using stem cells have brought to light some misconceptions about regenerative medicine. Legal issues and ethical concerns surround regenerative medicine because the technology uses living cells or plasma that is rich in platelets, particularly from stem cells that are embryonic. These aid regenerative treatments and medicine in imitating the stem cell’s original setting from which they are drawn. This allows the new cells to function as they do in their native tissue environment.

Stem cell treatment does not have FDA approval, but FDA approval is not required when therapies use adult stem cells, or the kind involved in regenerative medicine. Furthermore, physicians often prescribe “off label” treatments, or the use of an approved treatment for a condition not specified by FDA approvals. In such cases, physicians prescribe “off label” treatments when they believe from emerging studies and clinical experience that it will benefit the patient.

What Is Chronic Pain?

Chronic pain is a condition that is very common. Muscle and skin pain, or muscle and bone (musculoskeletal) pain, is one of the primary causes of protracted impairment in the U.S. Pain that is chronic can have a negative impact on your daily functioning. Chronic muscle and bone pain, in particular, is one of the leading reasons for physician appointments.

Chronic and acute pain conditions are a serious public health concern. Some experts suggest that some form of pain will interfere with the daily functioning of 90% of the population at some point in their lifetime. Some estimate that back pain causes annual costs—from medical expenses and loss of productivity—exceeding $100 billion. Besides causing high medical expenses and diminished productivity, pain that is chronic has other negative effects on your daily functioning at home and work, including absences and gravitation towards a sedentary lifestyle.

A number of original sources and degenerative processes or pathologies can cause pain that is chronic, including damage to the joint, muscle, or ligaments in the spinal region. Although the specific symptoms and sensations vary and they change over time, back and neck pain usually present as sensations of discomfort that originate in the back and radiate out toward the limbs. Sometimes the pain manifests as highly specific sharp stabbing sensations. Sometimes it presents as more widespread and generalized pain. Recurring symptoms might come and go, and different environmental circumstances might exacerbate pain symptoms. The cluster of symptoms depends on the underlying cause of the pain.

However, there are some common complaints including:

  • Muscle spasms
  • Stiffness
  • Cramps
  • Radiating pain
  • Numbness or weakness
  • Tingling or sensitivity to pressure or touch

Tissue damage or an underlying injury is usually the cause of pain in the body.

Several treatments are available to manage chronic pain. However, when first line treatments do not work, regenerative treatments and medicine often present a viable solution to mitigate symptoms and alleviate pain by addressing the underlying causes of the pain.

History Of Regenerative Treatments And Medicine

Regenerative medicine emerged from multidisciplinary scientific and technological advances. Although a relatively new procedure, regenerative treatments and medicine actually has origins that date back to tissue-based procedures from early skin grafting techniques and the first synthetic skin substitution in 1962. Skin was the first bioengineered tissue. Next, scientists successfully bioengineered cartilage. Skin and cartilage produced from tissue engineering are both commercially available to health care providers today.

The History of Regenerative Medicine
3000 BCArcheologists find descriptions of skin grafting in Sanskrit texts of India
1874European scientists achieve skin grafting technique using a person’s own cells
1881First allograft with cadaver skin
1944Scientists develop skin allografts chilled in refrigerators
1949Scientists develop cell cryopreservation at subzero temperatures
1952Scientists develop skin cryopreservation
1962Scientists create an artificial skin—the Ivalon sponge
1975Scientists cultivate keratinocytes in living organisms
1979Scientists create cultured autologous epithelium (later sold as Epicel)
1982Scientists create a collagen-glycosaminoglycans (CAG)-based dermal matrix (sold as Dermal Regeneration Template)
1987Scientists invent the term “tissue engineering”
1988Scientists master cell transplantation procedures in manmade easily-decomposed polymers
1994Scientists perform chondrocyte transplant and culture (sold as Carticel)
2006Scientists culture in living organisms and implant the first biologically-artificial bladder
2008Scientists produce the first biologically-engineered trachea from decellularized matrices cultivated with human cells from stem cells

Doctors performed the first successful tissue-engineered transplants in the 1970s. Howard Green and his team at Harvard Medical School grew skin epidermis by harvesting a skin biopsy. Regenerative therapy borrowed techniques from stem cell treatment via transplants of bone marrow to help individuals suffering from leukemia. 

Regenerative Medicine Methods And Procedures

Once diagnosed with pain and, often, after first line treatments fail, patients are referred to regenerative medicine experts so that they can undergo an initial consultation. Some patients with a variety of conditions experience benefits from regenerative treatments and medicine treatments. However, some cases do not respond to regenerative treatments. More aggressive treatments are available for intractable, debilitating symptoms of chronic and acute pain conditions.

By and large, in regenerative treatment, physicians extract a person’s own stem cells and other supporting cells from stem cell rich sites on the body. Then they filter, distill, and inject the unadulterated, extraction concentrate into the damaged tissue.

Regenerative medicine procedures normally take approximately 30 minutes. Regenerative treatments and medicine specialists see patients in clinic (not in hospitals) and can typically complete the procedure without general anesthesia on an outpatient basis with no recovery period. Patients return to their usual work and lifestyle activities immediately after the procedure. Most individuals report very little discomfort, with others reporting some additional mild bruising and minor soreness at the site of the injection.

Benefits Of Regenerative Treatments

Potential benefits include the following:

  • Significant improvements—renewal and repair—in joint, tendon, and ligament function
  • Very little pain or discomfort
  • Faster time to recovery and not very much “downtime” compared to surgery
  • Avoiding incisions, trauma, or general anesthesia common to surgery
  • Very low risk for allergic reaction or adverse effects

Regenerative Medicine Procedure Types

Commonly, three kinds of regenerative treatments and medicine are used for muscle and bone (musculoskeletal) pain that is chronic.

Using Stem Cells For Therapy

Stem cell treatment is the first kind of regenerative treatment and medicine. Stem cells naturally renew themselves through cell division and transform into a very broad spectrum of various kinds of body tissue. Stem cells reside in many sites throughout the human body, including the skin, bone marrow, blood (placental and peripheral), and tissue (placental and adipose). In the main, embryonic and adult are the primary kinds of stem cells.

In the 1960s, doctors used stem cell therapy (SCT) to treat individuals with leukemia and other conditions that require transplantation of cells from bone marrow (BMTs). Transplants of bone marrow often involve transplanting stem cells from compatible donors to patients.

Nowadays, physicians use stem cell treatment to treat many recurrent pain ailments. Usually, regenerative treatments and medicine involves taking out someone’s stem cells and additional, complimentary cells from stem-cell-rich sites on the body, then purifying, concentrating, and injecting the ingredients to create a precisely-mixed extract into the injured or weakened tissue.

Stem cell procedures are usually performed without the need for surgery. Afterwards, patients experience very short time to recovery. Stem cell therapy has potential to help people not require having surgery and help them avoid the side effects that come with surgery. Regenerative treatments and medicine using stem cell therapy for pain is usually non-surgical with very short time to recover and mild side effects, including some irritation at the location or place on your body where they injected the cells, and possibly some bruising.

Stem cell therapy as regenerative treatments and medicine for pain has been effective for people with low back or neck pain caused by degenerated vertebral discs or joint pain in the shoulders, hips, or knees caused by osteoarthritis.

Using Amniotic Membrane For Therapy 

Amniotic membrane therapy (AMT) is another form of regenerative treatment and medicine for chronic pain. Several unique properties comprise the amniotic membrane in humans. This trait makes it optimal for regenerative treatment and medicine. First of all, two sorts of cells comprise the membrane: epithelial and stromal cells. Both are comparable to stem cells because they can specialize or differentiate into different tissue types in living organisms. Prior studies and literature on using amniotic membrane animal models show that, following laminectomy (a minimally-invasive surgical procedure), amniotic membrane therapy can diminish scar tissue developing (known as epidural fibrosis), and scar adhesion occurring. Research and studies on using amniotic membrane for treatment in human prototypes suggest that it is effective for treating tendonitis and other overall tissue damage.

Amniotic membrane therapy is similar to stem cell treatment. It involves injecting a concentrated compound of your own amniotic membrane into the site of the injury. Also similar to stem cell therapy, and unlike surgery, amniotic membrane therapy can be a less intrusive therapy for chronic pain. It is usually performed without the need for surgery, and with modest recovery time and side effects. Amniotic membrane therapy patients can avoid disability and additional unexpected results often associated with major surgery. Minor side effects can include some irritation at the location or place on your body where they injected the cells and possible bruising.

Using Platelet-Rich Plasma For Therapy

Platelet Rich Plasma InjectionFirst used in the 1970s, platelet-rich plasma was developed into a therapy that targets a host of assorted recurrent pain conditions that are chronic, as well as for orthopedic and plastic surgery, sports medicine, and wound care. The methods include the following procedures. First, doctors inject a refined, compound of platelets, growth factors from the person’s body, platelets from the blood and plasma, and proteins related to secretion at the site of an injury to mend impaired tissue.

Scientists use a sample of blood from the patient to create the commixture for plasma that is platelet-rich requires for use. Centrifuges separate from the blood the virtually-transparent liquid called serum (in the top level) from the platelets, blood cells that are white (in the middle level), and the blood cells that are red (in the bottom level). It is understood that the middle layer is comprised of a platelet compound of around 1 million platelets/uL. Typically, a platelet compound expresses itself in a range between 150,000-350,000 platelets/uL. Furthermore, this fluid has a very high growth factor (up to three to five times greater). More specifically, synthesizing platelets and releasing proteins can aid in the underpinning procedures in creating new tissue—namely, recruiting, proliferating, and differentiating cells. This concentration of highly potent growth factor makes plasma that is platelet-rich promising for having a regenerative effect on damaged tissue.

According to extensive literature on the subject, therapy using plasma that is platelet-rich may improve cell proliferation, collagen production, gene expression, and matrix synthesis in tendons.

Research suggests that treatments using plasma that is platelet-rich has beneficial potential for treating tendinopathy in the Achilles heel, tendinopathy in the rotator cuff, lateral epicondylitis, patellar tendinopathy, tears in the rotator cuff, tears in the forward (anterior) cruciate ligament, osteoarthritis, and medial collateral ligament. It may also help treat pain conditions that are chronic and acute, such as muscle strain, arthritis, arthrofibrosis, tendonosis, muscle fibrosis, meniscal injury, defects in the articular cartilage, chronic synovitis, and joint inflammation. As they do with other forms of regenerative medicine, physicians inject this concentrated compound into the injury site, where the platelets create and release active proteins. Very short time to recovery and not many risks are associated with the treatment. Mild side effects include some irritation at the location or place on your body where they injected the cells and possible bruising

Types Of Pain Conditions That Can Be Treated With Regenerative Medicine

Patients who suffer from a range of conditions involving chronic pain—such as muscle and bone (musculoskeletal) conditions—might do well to try regenerative therapy.

Traditional therapies for the pain conditions mentioned above only help alleviate the incapacitating pain. Usually, they do not address the fundamental damage or condition causing the pain. Regenerative treatments and modern medicine has yielded advancements and made more options available for treatment for pain that is chronic, with a difference. Regenerative medicine treatments aim to correct the underlying issue causing the pain insofar as the injected compounds help promote the healing process natural to the human body by encouraging cell and tissue regeneration.

You might want to ask your doctor if your case is a good one for regenerative medicine therapy if you suffer from any of the following conditions.

Cervical Radiculopathy

This recurring pain condition happens when a spinal disc in the neck pushes against the cervical nerve and causes pain to travel down the arms. Sometimes it is called a pinched nerve. Young adults commonly get this condition from a herniated disc or an injury. When older adults suffer from these symptoms, it is usually caused by osteophyte formation from degeneration in the intervertebral joints, narrowing of the foraminal, and decreased disc height. Some of the treatments for cervical radiculopathy include watchful waiting, using soft collars, engaging in physical therapy, taking medication, and undergoing surgery.

Compression Fractures

Vertebral-Compression-FractureCompression fractures are usually bones in the spine that have compacted and shrunk in height. They can happen when a person suffers strain or distress to his or her back. Post-menopausal women very commonly suffer from osteoporosis. The condition is also common in people who have used corticosteroids for a long time. One study examined 7,000 women ages 66 and over for a four year period. It reported that 5% of the participants had developed compression fractures. Other studies found that compression fractures are the source of about 4% of participants over age 18 with back pain symptoms who had medical appointments with primary care providers.

Degenerative Disc Disease 

As people age, their intervertebral discs age as well. This aging can produce rips and alterations to their backs. This damage is believed to be the cause of the pain that comes with this disease, which is typified by the deterioration of back discs. Some patients experience the pain throughout their spines; some experience pain restricted to the intervertebral discs that are degenerating. Traditional treatments for disc disease—such as medicine you can buy at the pharmacy without a prescription and pain medications prescribed to you by your doctor, injections of steroid, physical therapy, and surgery for spinal fusion—helped patients manage the pain. New advances include using stem cell treatment or extracting stem cells from the person who will also receive the injection. This is usually procured from the hip, which is ideal when scientists obtain bone marrow. Doctors then concentrate the marrow and inject it directly into the location of the damaged tissue.

Herniated Disc

When a person experiences injured intervertebral discs, and the injury causes those discs to swell or tear, the condition is called a herniated disc. In the spine, intervertebral discs suffer a substantial degree of strain daily. Intervertebral discs enlarge and put stress on the column of your spine and put stress on the nerves that surround that column. This stress is what most experts believe is the origin of substantial pain. This condition, called a herniated disc, is common among the elderly.

Traditional treatments such as physical therapy that show some promise for healing herniated discs often require a long period of treatment. Additional treatments such as surgical procedures that remove the bulging disc material involve several risks, including the prospect of weakened discs from the surgery and added danger for experiencing problems with this condition in the future. New techniques within regenerative medicine—where doctors use a person’s stem cells, platelets, and other supporting cells to regenerate and rebuild the cells that make up the damaged disc—avoid traditional risks.

Lumbar Radiculopathy

Sciatica, or lumbar radiculopathy, occurs when a nerve root in your spine is weakened or damaged and a herniated disc—between the first sacral spinal nerve and the fifth lumbar (L5) of the spine—pushes against a nerve, sending jolts of pain down the leg. The lumbar are in the lower back area. Traditional therapy—such as physical therapy, anti-inflammatory pain medications, or steroid injections—reduce the size of the disc to decrease pressure on the nerve root. When the various treatments available prove ineffective for pain relief, stem cell repair may be an appropriate alternate treatment.


Osteoarthritis2Osteoarthritis is a very common type of arthritis. Osteoarthritis is a chronic degenerative joint condition involving wide-ranging cartilage degeneration from a specific injury or from wear and tear over several years. Osteoarthritis occurs anywhere in your body, but usually in hips, knees, and neck, back, and hand joints. There is a high risk of bone rubbing onto bone if cartilage sustains enough damage. There is no cure for this condition, only treatment options for managing the pain. Stem cell therapy may be more appropriate, since its mode of action is to repair and improve existing tissue. Typical treatments for osteoarthritis include taking anti-inflammatory pain medication, engaging in occupational and physical therapy, wearing special shoes or braces, taking steroid and lubrication shots, using a chiropractor, or having surgery to replace joints.

Plantar Fasciitis

Pain in the foot and pain in the heel can be chronic. When it is, it can be a condition called plantar fasciitis, which is the name of the flat, wide connective tissue on the back of the foot that attaches the ball of your foot to your heel. It also supports the arch of your foot. Small rips on the tendons themselves are a risk when this tissue becomes strained. Traditional treatments for plantar fascia help manage the symptom of pain. New regenerative medicine treatments stimulate the natural healing process that the body initiates to heal damaged tissue, or the cause of the pain. Empirical evidence suggests that therapy using rich plasma rich with platelets is quite effective for treating plantar fascia.


Spondylolisthesis is a degenerative condition, often classified as nonspecific low back pain, which involves the vertebrae or the individual bones of the spine. Spondylolisthesis occurs when the vertebra dislocates and “slips” over another, most often due to degenerative disc disease. Many patients with this condition do not suffer from any related symptoms, such as pain. But ultimately, the nerves around the weakened and slipped vertebrae can become compressed. Prevalence rates estimate that about 12% of the population experiences difficulties from spondylolisthesis. Many people with spondylolisthesis for whom traditional treatments do not work become surgery candidates. 

Spinal Stenosis

Spinal stenosis is characterized by neurogenic claudication or inflamed nerves spreading out from the spinal cord. Spinal stenosis causes the spinal column to narrow and the spinal canal to restrict. Older people are often at high risk of developing the condition spinal stenosis. As people age, they use their spine more and more, and the years of usage cause gradual and natural erosion of the parts of the spine. Symptoms of spinal stenosis include pain while walking. Doctors typically recommend more conservative forms of treatment before attempting regenerative treatments and medicine intervention.

Spinal Deformities

Spinal deformities are rare conditions that are typically characterized by genetically-linked curvature of the entire spine (also known as scoliosis, lordosis, or kyphosis). Different spinal deformities occur in different locations on the spine, and they involve different irregularities or malformations. Sometimes damage to the spine can cause spinal deformities. Although recent prevalence rates are not available, prior research estimates spinal deformities affect about 0.8% to 1.9% of the general population. Typical treatments include rehabilitation, pain medicine, surgery, orthotics, and braces, to name a few.

Sacroiliac Joint Pain

Sacroiliac joint pain affects the sacroiliac joint, which is situated at the bottom of your spine and which connects your hip to your spine. Although in many cases an injury precedes the onset of pain, injuries are not the cause of virtually all instances of pain in the sacroiliac joint. The partial therapies that are available to help manage sacroiliac joint pain—radiofrequency (neurotomy and pulsed) and injections of steroids—are typically insufficient. Limited evidence suggests that regenerative methods are effective in giving pain relief for this condition; some evidence shows that benefits from prolotherapy last longer than those from steroid injections.

Failed Back Surgery

Failed back surgery occurs when an original surgery to provide pain relief does not accomplish its goal. Sometimes, back pain is so severe that it requires surgery to provide some relief. But some people still suffer from back pain after surgery because of the invasiveness of the surgery. Scarred tissue forms around spinal nerves following surgery. It can cause lower back pain. Surgery can also cause reduced joint mobility; persistent pressure and stress on the spinal nerve after the surgery; and weakened discs and further herniation. People are also at increased risk of developing chronic back pain after surgery when they have a history of depression, difficulty falling or staying asleep, or a history of anxiety, depression, or difficulty falling asleep or staying asleep. Distributed, dull, throbbing pain along the back and in the lower limbs, and sharp, acute pain in bodily limbs are two symptoms of failed back surgery. When traditional treatments fail to provide relief from unsuccessful back surgery, physicians consider regenerative medicine as another option. 

How To Begin The Process

The main goal of regenerative therapy is to extract, refine, and concentrate healthy cells from a person and then inject that compound into the same person to grow those healthy cells into substitute body tissue that replaces and restores old, damaged, and weakened tissue. Regenerative therapy employs top advances from several fields: chemistry, medicine, engineering computer science, and robotics to engineer biological, organic tissues.

Since many pain conditions that are chronic and acute involve weakened, damaged, or aged tissue in the bone, tendon, cartilage, muscle, and other parts of the body, regenerative medicine promises to be a very effective alternative to current treatments for these conditions. Traditional treatments for these conditions primarily address the symptoms—such as moderating and lessoning the pain. And the traditional treatments can include extreme and invasive procedures such as surgery. Since the target goals of regenerative medicine are to catalyze and augment the body’s natural healing processes by using healthy cells to support and regenerate injured ones, regenerative medicine might ultimately help pain conditions that are chronic and acute more so than traditional therapies.

Although regenerative medicine is not approved for all pain conditions, limited research suggests that it might provide relief for chronic and acute pain by injecting regenerated cells and tissues to help the body heal itself at the location of the pain. But that evidence suggests that regenerative treatments and medicine can provide relief for several pain conditions that fail to respond to first-line interventions. There have been great advances and improvements in regenerative treatments and medicine procedures. Therefore, future studies may provide more evidence that regenerative medicine is an effective treatment for pain that is chronic.

Regenerative treatments and medicine are comparatively safe and easy. It is usually performed on an outpatient basis. How does the treatment work? It begins when doctors extract a person’s own stem cells and additional secondary cells from stem-cell-rich sites on their body. Doctors purify, concentrate, and inject this material into damaged tissue, taking care not to alter the concentration at all. The procedure typically causes a very small degree of discomfort, with minor side effects such as soreness and mild bruises at the injection site.

Ask your doctor if and which regenerative treatments are right for you. If you want to find out whether regenerative medicine is appropriate for providing relief for your pain condition, attend a consultation with a physician who specializes in regenerative medicine. Consultation appointments provide you with the information you need to answer your questions and concerns. They usually include an in-depth medical evaluation of the underlying condition, a review of your brief-but-detailed personal medical history, the potential for using regenerative treatments and medicine to treat it, an assessment of your degree of risk for difficulties, and guidance about what to expect regarding the procedures involved in regenerative medicine. These consultations can also help clear up misconceptions about using regenerative stem cell treatments. The objective of the consultation is to ensure an accurate diagnosis of the source of the pain so that the physician can determine the most appropriate regenerative medicine procedure. The precise cause of some cases of pain that is chronic is unclear. In these cases, it is important to ensure that certain diagnoses are ruled out.

NOTE: When adult stem cells are autologous, it means that scientists take those cells from an adult and then they inject those cells into the same person. The FDA has not currently mandated approval requirements for collecting these stem cells, nor has it given permission to use stem cells in the prevention, treatment, or curing of aging or any medical condition or disease discussed in this essay.

At Pain Doctor our goal is to relieve your pain and improve function to increase your quality of life.
Give us a call today at 480-563-6400.


  1. Barboni B, Russo V, Curini V, et al. Achilles tendon regeneration can be improved by amniotic epithelial cells allotransplantation. Cell Transplant. 2012:[Epub ahead of print].
  2. Díaz-Prado S, Muiños-López E, Hermida-Gómez T, et al. Human amniotic membrane as an alternative source of stem cells for regenerative medicine. Differentiation. 2011;81(3):162-171.
  3. Giusti I, Rughetti A, D’Ascenzo S, et al. Identification of an optimal concentration of platelet gel for promoting angiogenesis in human endothelial cells. Transfusion. 2009;49(4):771-778.
  4. Hyun I. Allowing innovative stem cell-based therapies outside of clinical trials: Ethical and policy challenges. J Law Med Ethics. 2010:38(2):277-85.
  5. Masuda K, Lotz JC. New challenges for intervertebral disc treatment using regenerative medicine. Tissue Eng Part B Rev. 2010;16(1):147-58.
  6. McJunkin T, Lynch P, Deer TR, Anderson J, Desai R. Regenerative medicine in pain management. Pain Medicine News Spec. 2012:35-38.
  7. Nguyen R, Borg-Stein J, McInnis K. Applications of platelet-rich plasma in muscle and bone (musculoskeletal) and sports medicine: A evidence-based approach. PM&R. 2011:3(3):226-250.
  8. Ohno T, Kaneda H, Nagai Y, Fukushima M. Regenerative medicine in critical limb ischemia. J Atheroscler Thromb. 2012;19(10)883-9.
  9. Van Osch GJ, Brittberg M, Dennis JE, Bastiaansen-Jenniskens YM, Erben RG, Knottinen YT, Luyten FP. Cartilage repair: Past and future—lesson for regenerative medicine. J Cell Mol Med. 2009;13(5):792-810.
  10. Vora A, Borg-Stein J, Nguyen RT. Regenerative injection therapy for osteoarthritis: Fundamental concepts and evidence-based review. PM R. 2012;4(5 Suppl):S104-9.